ABSTRACT
Castelman's disease, an unusual condition of unknown cause, consisting of a massive proliferation of lymphoid tissue. Three histologic variants [hyaline vascular, plasma-cell, and mixed] and two clinical types [localized and multicentric] of Castelman's disease have been described.Localized disease can be cured with surgery or radiotherapy, but complete remission in patients with multicentric disease have been achieved only with prednisone or chemotherapy given at the time of diagnosis.The aim of this study is to report two cases of retroperitoneal Castelman's disease with review of the literature.the first patient, of 36 years old, presented for abdominal pain with anorexia and weight loss. The abdomino-pelvic CT scan showed a 6 cm retroperitoneal mass. The biopsy of this lesion suspected a lymphoproliferative disease. At laparotomy total excision of mass was made and the final histology revealed a hyaline-vascular type of Castelman's disease.The second patient, of 26 years old, presented for left lumbar pain with weight loss. The abdominopelvic CT. Scan showed a 6.5 cm retroperitoneal mass.The biopsy of this lesion showed a Castelman's disease. At laparotomy total excision of mass was made and the final histology confirmed a hyalinovascular type of Castelman's disease